NCIt definition : Autologous cytotoxic T-lymphocytes (CTLs) specifically reactive to the tumor-associated
antigen (TAA) human carcinoembryonic antigen (CEA), with potential antineoplastic
activity. Dendritic cells (DCs) isolated from the patient's blood are infected with
recombinant adeno-associated virus (AAV) expressing the CEA gene. Exposure of T-lymphocytes
to DCs creates CEA-specific CTLs which are expanded. Upon reintroduction of these
CTLs into the patient, these cells recognize and kill CEA-expressing tumor cells.
CEA, a tumor-associated antigen and a member of the CEA family of proteins, plays
a key role in cell migration, cell invasion, and cell adhesion and is overexpressed
by a variety of cancer types.;