" /> Autologous Anti-B7-H3 CAR T-cells TX103 - CISMeF





Preferred Label : Autologous Anti-B7-H3 CAR T-cells TX103;

NCIt synonyms : Autologous CAR-T Cells TX103; Autologous Anti-B7-H3 CAR-T Cells TX103;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T-cells TX103 target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis.;

Molecule name : TX-103; TX 103;

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30/07/2025


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