NCIt synonyms : UF-KURE19 CAR-T Cells; Autologous Anti-CD19 CAR T-cells UF-KURE19; Autologous Anti-CD19 CAR T Cells UF-KURE19;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified and
transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) that
targets the human tumor-associated antigen (TAA) CD19, with potential immunostimulating
and antineoplastic activities. Upon administration, autologous anti-CD19 CAR-expressing
T-lymphocytes UF-KURE19 bind to and induce selective toxicity against CD19-expressing
tumor cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed
in all B-cell lineage malignancies.;