Preferred Label : Autologous Anti-CD19 T-cell Receptor T cells ET190L1;
NCIt synonyms : ET190L1-ARTEMIS (TM); ET190L1-ARTEMIS (TM) T Cells;
NCIt definition : Autologous human peripheral blood T-lymphocytes transduced with a lentivirus encoding
a proprietary expression construct composed of a T-cell receptor (TCR)-like human
antibody, which is synthesized by a proprietary phage display platform, targeting
peptides derived from the tumor-associated antigen (TAA) CD19 that are presented in
the context of major histocompatibility complex (MHC) molecules, with potential antineoplastic
activity. Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction,
and re-introduction into the patient, the autologous anti-CD19 TCR T-cells ET190L1
target and bind to tumor cells expressing CD19 peptide/MHC complexes. This results
in cytotoxic T-lymphocyte (CTL)-mediated elimination of CD19-positive tumor cells.
CD19, cluster of differentiation antigen 19, is a B-cell-specific cell surface antigen
overexpressed in B-cell lineage malignancies. ET190L1 is able to match the anticancer
activity of chimeric antigen receptor (CAR) T-cells; however, ET190L1 is less likely
to stimulate cytokine release syndrome (CRS) and does not cause CAR T-cell-triggered
neurotoxicity.;
Molecule name : ET190L1; ET 190; ET190;
NCI Metathesaurus CUI : CL545822;
Origin ID : C148030;
UMLS CUI : C4688337;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
