Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T Cells - CISMeF
Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T CellsNCIt concept
Preferred Label : Autologous Anti-B7-H3 CAR Retroviral Vector-transduced T Cells;
NCIt synonyms : Autologous B7-H3 CAR-retroviral Vector-transduced T Cells; Autologous B7-H3-targeting CAR T Cells;
NCIt definition : A preparation of autologous T-lymphocytes that have been transduced with a retroviral
vector expressing a chimeric antigen receptor (CAR) targeting the immunoregulatory
protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory
signaling domains, with potential immunostimulating and antineoplastic activities.
Upon infusion back into the patient, autologous anti-B7-H3 CAR retroviral vector-transduced
T cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective
toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and
a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain
tumor cell types and on various immune cells. It is a negative regulator of the T-cell
activation and its overexpression plays a key role in tumor cell invasion and metastasis.;