" /> Autologous Anti-L1CAM-CAR-EGFRt-expressing T-cells - CISMeF





Preferred Label : Autologous Anti-L1CAM-CAR-EGFRt-expressing T-cells;

NCIt synonyms : Autologous L1CAM-specific CAR EGFRt T-cells; Autologous CD171-specific CAR-EGFRt-expressing T Lymphocytes;

NCIt definition : A preparation of autologous human T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for the L1 cell adhesion molecule (L1CAM; L1-CAM; CD171) antigen and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon re-infusion into the patient, the autologous anti-L1CAM-CAR-EGFRt-expressing T-cells are directed to and induce selective toxicity in L1CAM-expressing tumor cells. L1CAM, a neuronal cell adhesion molecule and member of the L1 protein family, plays a key role in the development of the nervous system; it is overexpressed in various tumor cell types and is associated with increased chemoresistance, tumor progression, migration and metastasis. Devoid of both ligand-binding domains and tyrosine kinase activity, EGFRt facilitates both the detection of the administered T-cells in vivo and the elimination of the modified T-cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response.;

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16/05/2024


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