" /> Autologous BAFFR-targeting CAR T Cells - CISMeF





Preferred Label : Autologous BAFFR-targeting CAR T Cells;

NCIt synonyms : Autologous BAFFR-CAR T Cells; Autologous BAFFR-CAR-expressing T-cells;

NCIt definition : A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) B-cell activating factor receptor (BAFFR; tumor necrosis factor receptor superfamily member 13C; TNFRSF13C; BLyS receptor 3; BR3), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BAFFR-targeting CAR T cells are directed to and induce selective toxicity in BAFFR-expressing tumor cells. BAFFR, a protein belonging to the TNF receptor superfamily, is expressed on the surface of certain types of cancer cells, including B-cell acute lymphoblastic leukemia. It plays a key role in the regulation of peripheral B-cell survival.;

NCI Metathesaurus CUI : CL1647969;

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15/05/2024


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