Autologous Memory Cytokine-enriched Natural Killer Cells

Preferred Label : Autologous Memory Cytokine-enriched Natural Killer Cells;

NCIt synonyms : Autologous M-CENKs; Autologous m-ceNK Cells; Autologous Memory Cytokine-enriched NK Cells; Autologous Cytokine-induced Memory-like NKs; Autologous Memory Cytokine-Enhanced NK Cells; m-ceNK (TM);

NCIt definition : A population of cryopreserved, autologous CD56-positive memory cytokine-enriched natural killer (NK) cells (m-ceNKs), armed with NK cell-activating surface receptors, with potential immunomodulating and antitumor activities. Autologous NK cells are pre-activated ex vivo with a cytokine cocktail, which induces the differentiation of the NK cells into immune-memory m-ceNKs, which possess a unique phenotype. The pretreated NKs exhibit enhanced cytotoxicity and increased interferon-gamma (IFN-g) production. Upon administration, the autologous m-ceNKs may recognize and kill tumor cells.;

NCI Metathesaurus CUI : CL1663478;

Details

Origin ID

C180827;

UMLS CUI

C5556651;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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