NCIt definition : A cancer vaccine consisting of a truncated recombinant HER2 peptide (dHER2) with potential
antineoplastic activity. Upon administration, recombinant dHER2 vaccine may stimulate
the host immune response to mount a cytotoxic T-lymphocyte response against tumor
cells that overexpress the HER2 protein, resulting in tumor cell lysis. The HER2 protein
is a tumor-associated antigen (TAA) that is overexpressed in a variety of cancers.
dHER2 includes the extracellular domain (ECD) and a part of the intracellular domain
(ICD) of the HER2 protein.;