Autologous MG7-pulsed Dendritic Cell Vaccine

Preferred Label : Autologous MG7-pulsed Dendritic Cell Vaccine;

NCIt synonyms : Autologous MG7-pulsed DC Vaccine; MG-7 Antigen-pulsed Autologous DC Vaccine; MG7-DC Vaccine; Autologous MG-7-pulsed Dendritic Cell Vaccine;

NCIt definition : A dendritic cell (DC)-based cancer vaccine composed of autologous DCs pulsed with the human gastric carcinoma-associated antigen MG7, with potential immunostimulatory and antineoplastic activities. Upon administration at the inguinal lymph nodes, autologous MG7-pulsed DC vaccine may stimulate the immune system to mount an anti-tumoral cytotoxic T-lymphocyte (CTL) response against MG7-expressing tumor cells, which may result in tumor cell lysis. MG7, a glycosylated protein sequence from the tumor-associated antigen (TAA) carcinoembryonic antigen (CEA), plays a key role in the development of certain tumor cell types.;

NCI Metathesaurus CUI : CL1648146;

Details

Origin ID

C178445;

UMLS CUI

C5555038;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- MG7 Antigen [NCIt concept]

Keyword's position in hierarchy(ies) :

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