Autologous Gene-modified PD-1-positive T-lymphocytes Sc610

Preferred Label : Autologous Gene-modified PD-1-positive T-lymphocytes Sc610;

NCIt synonyms : Autologous Gene-modified PD-1-positive T-cells Sc610;

NCIt definition : A preparation of autologous programmed cell death protein 1 (PD-1; PDCD1; CD279)-positive T-lymphocytes transduced with a lentiviral vector encoding for an as of yet undisclosed receptor, with potential immunostimulatory and antineoplastic activities. Upon administration, autologous gene-modified PD-1-positive T-lymphocytes Sc610 bind to tumor cells expressing the antigen for the as of yet undisclosed receptor, which may result in specific cytotoxic T-lymphocyte (CTL)-mediated tumor cell killing.;

Molecule name : Sc 610; Sc-610;

NCI Metathesaurus CUI : CL1906414;

Details

Origin ID

C198984;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

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