NCIt definition : A preparation of autologous tumor-infiltrating lymphocytes (TILs) derived from a patient's
tumor that have been stimulated ex vivo with CD40 ligand (CD40L, tumor necrosis factor
superfamily member 5, TNFSF5, CD154, TNF-related activation protein, TRAP, gp39) during
cell expansion, with potential immunomodulating and antineoplastic activities. Upon
administration, the CD40L-augmented autologous TILs specifically recognize and kill
the patient's tumor cells. Stimulation with a CD40L may enhance both the expansion
of the TILs and the tumor-killing ability of the TILs when returned to the patient.;