" /> Autologous Anti-CDH17 CAR-T Cells CHM-2101 - CISMeF





Preferred Label : Autologous Anti-CDH17 CAR-T Cells CHM-2101;

NCIt synonyms : Autologous Anti-CDH17 CAR T-cells CHM-2101; Autologous Anti-cadherin-17 CAR-T Cells CHM-2101; CDH17 CAR T Cells CHM-2101; Autologous Anti-CDH17 CAR T Cells CHM-2101;

NCIt definition : A preparation of autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cadherin-17 (CDH17), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the autologous anti-CDH17 CAR-T cells CHM-2101 are reintroduced into the patient and are directed to tumor cells expressing CDH17, which may result in a selective toxicity against, and lysis of CDH17-expressing tumor cells. CDH17, a cell surface adhesion protein, is overexpressed in a variety of cancer cell types.;

Molecule name : CHM 2101; CHM-2101;

NCI Metathesaurus CUI : CL1920774;

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02/05/2025


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