" /> Dimerizing Agent Regulated Immunoreceptor Complex-expressing CD33-specific Autologous CAR T Cells SC-DARIC33 - CISMeF





Preferred Label : Dimerizing Agent Regulated Immunoreceptor Complex-expressing CD33-specific Autologous CAR T Cells SC-DARIC33;

NCIt synonyms : DARIC-expressing CD33-specific Autologous CAR T Cells SC-DARIC33; Seattle Children's DARIC33 Autologous CAR T Cells SC-DARIC33; DARIC33 Autologous CAR T-cells SC-DARIC33; DARIC-expressing Anti-CD33 CAR T Cells SC-DARIC33;

NCIt definition : A preparation of equal amounts of autologous CD4-positive and CD8-positive T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD33 and genetically modified to express a Dimerizing Agent Regulated Immunoreceptor Complex (DARIC), with potential immunomodulating and antineoplastic activities. Upon transfusion of the DARIC-expressing CD33-specific autologous CAR T-cells SC-DARIC33 and followed by intermittent low dose rapamycin administration, rapamycin binds to DARIC and activates the T-cells when binding to CD33-expressing tumor cells, thereby inducing selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells. The ability of rapamycin to control the activity of the DARIC cells may help control the toxicity of the CAR T-cells, prevent T-cell exhaustion and may help them last longer in vivo. Using the DARIC platform, the antigen recognition and signaling functions of a CAR are separated into two distinct polypeptides and engineered to contain the two interacting and dimerization domains, FK506-binding protein (FKPB12) and FKBP12-rapamycin-binding (FRB) protein. In the absence of the dimerizing drug rapamycin, the CAR T-cells lack signaling activity upon antigen recognition and binding. The administration of the dimerizing agent enables the two DARIC subunits to interact and thereby allows for the CAR T-cells to fully function and activate their signaling abilities upon antigen recognition.;

Molecule name : SC DARIC33; SC-DARIC33;

NCI Metathesaurus CUI : CL1772911;

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15/05/2024


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