NCIt related terms : SELECTIKINE; Interleukin-2 Fusion Protein MSB0010445;
NCIt definition : A fusion protein consisting of a mouse-human chimeric antibody directed against DNA
released by necrotic tumor cells fused to two molecules of a genetically modified
human interleukin-2 (IL-2) with potential antineoplastic activity. Upon administration,
the antibody moiety of immunocytokine NHS-IL2-LT binds to DNA released by necrotic
tumor cells located primarily at the core of necrotic solid tumors, delivering the
IL-2 moiety. In turn, the IL-2 moiety of this agent activates the immune system to
mount a cytotoxic T lymphocyte response against nearby tumor cells.;