Lifileucel - CISMeF

Preferred Label : Lifileucel;

NCIt synonyms : Autologous TIL LN-144; Autologous Tumor Infiltrating Lymphocytes LN-144; Contego;

NCIt related terms : Lifileuecel;

NCIt definition : A preparation of autologous tumor infiltrating lymphocytes (TILs), with potential antineoplastic activity. TILs are isolated from a patient's tumor tissue, cultured in vitro with high-dose interleukin-2 (lL-2), further selected based on antigen specificity and tumor reactivity, and the selected TILs are subsequently expanded. Upon re-introduction of lifileucel into the patient, the TILs re-infiltrate the tumor, specifically recognize the tumor-associated antigens (TAAs), and initiate tumor cell lysis. IL-2 induces the proliferation and expansion of TILs in vitro.;

UNII : R0835E18NH;

CAS number : 2306267-74-1;

Drug name : Amtagvi;

Molecule name : LN-144; LN 144;

Codes from synonyms : 114432;

Details

Origin ID

C120552;

UMLS CUI

C4053624;

Semantic type(s)
- Cell [UMLS semantic type]
UMLS correspondences (same concept)
- lifileucel [MeSH Supplementary Concept]
- lifileucel [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Lifileucel Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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