NCIt definition : Autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have
been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting
the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a
single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of
the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta
directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective
toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed
in all B-cell lineage malignancies.;