" /> Autologous TROP2-CAR-transduced PD-1-positive T Cells T60c - CISMeF





Preferred Label : Autologous TROP2-CAR-transduced PD-1-positive T Cells T60c;

NCIt synonyms : TROP2-CAR-transduced PD-1-positive T-cells T60c;

NCIt definition : A preparation of autologous programmed cell death protein 1 (PD-1; PDCD1; CD279)-positive T-lymphocytes transduced with a lentivirus expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1), with potential immunostimulating and antineoplastic activities. Upon administration, autologous TROP2-CAR-transduced PD-1-positive T-cells T60c target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.;

Molecule name : T 60c; T-60c;

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12/05/2024


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