HPV 16/18 E6/E7-encoding Lentiviral Vector-based Vaccine Lenti-HPV-07

Preferred Label : HPV 16/18 E6/E7-encoding Lentiviral Vector-based Vaccine Lenti-HPV-07;

NCIt synonyms : HPV 16/18 E6/E7-encoding Lentiviral Vector-based Therapeutic Vaccine Lenti-HPV-07; Lentiviral Vector-encoding HPV16/18 E6/E7 Lenti-HPV-07; HPV Therapeutic Vaccine Lenti-HPV-07;

NCIt definition : A cancer vaccine consisting of a non-integrative lentiviral vector encoding the detoxified forms of the human papillomavirus (HPV) subtypes 16 and 18 viral oncoproteins E6 and E7, with potential immunostimulating and antineoplastic activities. Upon administration, HPV 16/18 E6/E7-encoding lentiviral vector-based vaccine Lenti-HPV-07 may elicit a specific cytotoxic T-lymphocyte (CTL) response against cancer cells expressing the HPV 16/18 E6 and E7 oncoproteins, resulting in tumor cell lysis. HPV infections and HPV oncoproteins play a key role in the development of cervical and other cancers, including oropharyngeal and anogenital cancers.;

Molecule name : Lenti-HPV-07; Lenti-HPV 07;

Détails

Origin ID

C211920;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Human Papillomavirus [NCIt concept]

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