NCIt definition : A peptide vaccine consisting of a peptide derived from isocitrate dehydrogenase 1
(IDH1) containing the point mutation R132H (IDH1R132H), with potential antineoplastic
activity. Intradermal vaccination with the IDH1R132H-specific peptide vaccine PEPIDH1M
may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response
against tumor cells that express the IDH1R132H protein. The IDH1 point mutation of
amino acid residue 132 is highly expressed in gliomas and is associated with increased
production of the oncometabolite R-2-hydroxyglutarate (2HG).;