NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) specific for the immune inhibitory receptor leukocyte
immunoglobulin-like receptor B member 4 (LILRB4; ILT3; ILT-3), with potential immune
checkpoint inhibitory and antineoplastic activities. Upon administration, autologous
anti-ILT3 CAR-T cells target and bind to ILT3-expressing tumor cells. This results
in a cytotoxic T-lymphocyte (CTL) response against ILT3-expressing tumor cells. ILT3,
a tumor associated antigen (TAA) and an immune inhibitory receptor expressed on immune
suppressive myeloid cells, is highly expressed on certain hematologic cancer cells,
such as monocytic acute myeloid leukemia (AML) cells. It functions as an immune checkpoint
that negatively regulates T-cell activation as its extracellular domain inhibits T-cell
activity. It plays an important role in tumor infiltration, T-cell suppression and
immune tolerance.;