NCIt definition : A vaccine consisting of a replication-defective recombinant adenovirus that encodes
the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity.
Vaccination with gp100 adenovirus vaccine may stimulate the host immune system to
mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the
gp100 antigen, resulting in decreased tumor growth. (NCI04);