Autologous Anti-LGR5 CAR-T Cells CNA3103

Preferred Label : Autologous Anti-LGR5 CAR-T Cells CNA3103;

NCIt synonyms : LGR5-targeted Autologous CAR-T Cells CNA3103; Leucine-rich Repeat-containing G Protein-coupled Receptor 5-targeted Autologous CAR T-cells CNA3103;

NCIt definition : A preparation of autologous T-lymphocytes transduced to express a chimeric antigen receptor (CAR) targeting the cancer stem cell (CSC) marker leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-LGR5 CAR-T cells CNA3103 selectively target, binds to and lyse LGR5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival, tumor initiation, growth, and metastasis. Its expression is linked to poor survival and poor patient response to therapy. CNA3103 contains the antigen-biding domain of the humanized monoclonal LGR5 antibody BNC101.;

Molecule name : CAN-3103; CAN 3103;

NCI Metathesaurus CUI : CL1907131;

Details

Origin ID

C200325;

chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5 [NCIt concept]

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