Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5

Preferred Label : Leucine-Rich Repeat-Containing G-Protein Coupled Receptor 5;

NCIt synonyms : G-Protein Coupled Receptor 49; G-Protein Coupled Receptor HG38; G-Protein Coupled Receptor 67; Orphan G Protein-Coupled Receptor HG38; G Protein-Coupled Receptor 49; Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 5; LGR5;

NCIt definition : Leucine-rich repeat-containing G-protein coupled receptor 5 (907 aa, 100 kDa) is encoded by the human LGR5 gene. This protein plays a role in signal transduction.;

NCIt note : In contrast to classical G-protein coupled receptors, leucine-rich repeat-containing G-protein coupled receptor 5 does not appear to activate heterotrimeric G-proteins to transduce the signal. (UniProt);

Details

Origin ID

C101486;

UMLS CUI

C3640115;

Automatic exact mappings (from CISMeF team)
- Leucine-rich repeat-containing g protein-coupled receptor 5 [OMIM gene]
OMIM relation
- Leucine-rich repeat-containing g protein-coupled receptor 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- LGR5 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Leucine-Rich Repeat [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Wnt Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Autologous Anti-LGR5 CAR-T Cells CNA3103 [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients