NCIt definition : Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral
vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane
proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity. Vaccination
with Ad5F35-LMP1/LMP2-transduced autologous dendritic cells may stimulate a specific
cytotoxic T-lymphocyte (CTL) response against LMP1- and LMP2-expressing tumor positive
cells, resulting in tumor cell lysis and inhibition of tumor cell proliferation. LMP1
and LMP2 are expressed in various malignancies including nasopharyngeal cancer and
EBV-positive Hodgkins disease.;