Personalized Peptides-loaded Autologous Dendritic Cell Vaccine

Preferred Label : Personalized Peptides-loaded Autologous Dendritic Cell Vaccine;

NCIt synonyms : Autologous Dendritic Cell Vaccine Loaded with Personalized Peptides; PEP-loaded Autologous DC Vaccine; PEP-DC Vaccine;

NCIt definition : A cell-based personalized cancer vaccine composed of autologous dendritic cells (DCs) loaded with the patient's own tumor-specific peptides, with potential immunostimulatory and antineoplastic activities. Upon administration of the personalized peptides (PEP)-loaded autologous DC vaccine, the DCs activate natural killer cells (NKs) and stimulate a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells expressing the PEPs, resulting in tumor cell lysis.;

NCI Metathesaurus CUI : CL1661921;

Details

Origin ID

C179254;

UMLS CUI

C5555555;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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