Autologous Vaccine-enhanced Ex Vivo Activated Cancer Neoantigens-specific T-cells
TVI-Brain-1 - CISMeF
Autologous Vaccine-enhanced Ex Vivo Activated Cancer Neoantigens-specific T-cells
TVI-Brain-1NCIt concept
Preferred Label : Autologous Vaccine-enhanced Ex Vivo Activated Cancer Neoantigens-specific T-cells
TVI-Brain-1;
NCIt definition : A preparation of autologous T-lymphocytes collected from the patient after the administration
of a personalized cancer vaccine composed of an attenuated form of patient-specific
cancer cells and an immunological adjuvant, via leukapheresis, and activated ex vivo,
with potential immunostimulating and antineoplastic activities. Cancer neoantigens-specific
T-cells are collected after the administration of the personalized cancer vaccine
and expanded ex vivo. Upon administration, the autologous vaccine-enhanced ex vivo
activated cancer neoantigens-specific T-cells TVI-Brain-1 recognize and bind to tumor
cells expressing the cancer neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated
immune response against the patient's tumor cells.;