Autologous Alpha-PNE Switchable CAR-T Cells CLBR001

Preferred Label : Autologous Alpha-PNE Switchable CAR-T Cells CLBR001;

NCIt synonyms : Autologous Alpha-PNE CAR T-cells CLBR001; Autologous Alpha-peptide Neo-epitope CAR-T Cells CLBR001; Autologous Alpha-PNE CAR T-lymphocytes CLBR001; Autologous Alpha-PNE sCAR-T Cells CLBR001;

NCIt definition : A preparation of autologous T-lymphocytes that has been genetically engineered to express a switchable, alpha-peptide neo-epitope (PNE) chimeric antigen receptor (CAR) with a binding domain that can recognize a 14 aa peptide epitope, or PNE, of an antigen-specific adapter molecule, with potential immunomodulating and antineoplastic activities. Upon administration, autologous alpha-PNE switchable CAR-T (sCAR-T) cells CLBR001 remain inactivated. Upon administration of an antigen-specific adapter molecule, the binding domain of CLBR001 binds to the PNE of the adapter molecule, and CLBR001 is activated. This induces selective toxicity in and causes lysis of tumor cells expressing the specific antigen.;

Molecule name : CLBR 001; CLBR-001;

NCI Metathesaurus CUI : CL1413003;

Details

Origin ID

C175578;

UMLS CUI

C5446633;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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