Recombinant Fowlpox-TRICOM Vaccine

Preferred Label : Recombinant Fowlpox-TRICOM Vaccine;

NCIt synonyms : rF-TRICOM (B7.1.iCAM1-LFA3-Fowlpox); Recombinant Fowlpox-TRICOM; Fowlpox-TRICOM Vaccine;

NCIt related terms : rF-TRICOM;

NCIt definition : A vaccine comprised of a recombinant fowlpox virus vector encoding a TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3) (TRICOM), which may enhance antigen presentation and activate cytotoxic T-cells. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. (NCI04);

Alternative definition : NCI-GLOSS: A cancer vaccine made with a form of a chicken virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins that may help immune cells in the body kill tumor cells.;

NSC code : 710658;

Codes from synonyms : CDR0000573127; CDR0000543384;

Details

Origin ID

C2667;

UMLS CUI

C1134570;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Gene Regulation Process [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Fowlpox-Sargramostim Vaccine/Fowlpox-TRICOM Vaccine [NCIt concept]

Keyword's position in hierarchy(ies) :

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