MAGE-A3-expressing Adenovirus Type 5 Vaccine - CISMeF
MAGE-A3-expressing Adenovirus Type 5 VaccineNCIt concept
Preferred Label : MAGE-A3-expressing Adenovirus Type 5 Vaccine;
NCIt synonyms : AdMA3; Adenovirus/MAGE-A3;
NCIt definition : An oncolytic adenoviral vaccine composed of a replication-defective, E1- and E3-deleted
adenovirus serotype 5 (Ad5) with a transgene encoding the human melanoma antigen A3
(MAGE-A3), with potential antineoplastic activity. Upon administration, MAGE-A3-expressing
adenovirus type 5 vaccine selectively replicates in cancer cells and expresses MAGE-A3.
This induces an immune response against tumor cells expressing the MAGE-A3 antigen,
which leads to tumor cell death. The tumor-associated antigen MAGE-A3 is overexpressed
by a variety of cancer cell types.;