Preferred Label : Anti-CEA-CAR Autologous T Lymphocytes;
NCIt synonyms : Autologous Anti-CEA CAR-T Cells;
NCIt definition : Autologous lymphocytes transduced with a retroviral vector encoding a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen human carcinoembryonic antigen
(CEA), with potential immunostimulating and antineoplastic activities. Upon administration,
the anti-CEA-CAR autologous T-lymphocytes target and bind to tumor cells expressing
CEA, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of CEA-expressing
tumor cells. CEA is overexpressed in various tumor cell types.;