Personalized Neoantigen-specific T-lymphocytes NEO-PTC-01

Preferred Label : Personalized Neoantigen-specific T-lymphocytes NEO-PTC-01;

NCIt synonyms : Neoantigen-specific T-cells NEO-PTC-01; Autologous Personalized T Cells NEO-PTC-01; Personalized Neoantigen-targeted T Cells NEO-PTC-01; Autologous PTCs NEO-PTC-01;

NCIt definition : A preparation of autologous, personalized tumor neoantigen-specific T-lymphocytes, with potential immunostimulating and antineoplastic activities. The T-cells are derived from the patients' peripheral blood mononuclear cells (PBMCs) and are primed and activated against tumor-specific neoantigens that are expressed on the patient's tumor cells or in the tumor microenvironment (TME), and expanded ex vivo. Upon administration, the autologous neoantigen-specific T-lymphocytes NEO-PTC-01 recognize and bind to tumor cells expressing the targeted neoantigens, resulting in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the patient's tumor cells.;

Molecule name : BNT-221; PTC-01; PTC 01;

NCI Metathesaurus CUI : CL1661897;

Details

Origin ID

C179294;

UMLS CUI

C5555592;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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