" /> Autologous BCMA-targeted CAR T Cells CC-98633 - CISMeF





Preferred Label : Autologous BCMA-targeted CAR T Cells CC-98633;

NCIt synonyms : Autologous BCMA-targeted CAR T-cells CC-98633; Autologous BCMA-targeted NEX-T CAR T Cells CC-98633;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous BCMA-targeted CAR T cells CC-98633 specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma cell survival; it is found on the surfaces of plasma cells and overexpressed on malignant plasma cells.;

Molecule name : CC 98633; CC-98633;

NCI Metathesaurus CUI : CL1407516;

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Keyword's position in hierarchy(ies) : arborescence

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15/05/2024


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