Preferred Label : IL13Ralpha2-specific Hinge-optimized 41BB-co-stimulatory CAR Truncated CD19-expressing
Autologous T-Lymphocytes;
NCIt synonyms : Autologous IL13(EQ)BBzeta/CD19t TCM-enriched T Cells;
NCIt definition : A preparation of ex vivo expanded, genetically modified autologous central memory-enriched
T-cells (Tcm) transduced with a replication incompetent, self-inactivating (SIN) lentiviral
vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for
interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation
137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of
the T cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of
human cluster of differentiation 19 (CD19t), with potential immunostimulating and
antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific,
hinge-optimized, 41BB-co-stimulatory CAR/truncated CD19 expressing T-lymphocytes are
directed to, and induce selective toxicity and cytolysis in IL13Ra2-expressing tumor
cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with
increased tumor cell proliferation, migration and invasiveness. The costimulatory
signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge
optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors
(FcRs). CD19t is used as a surface marker to both quantify and track the gene modified
T-cells in vivo.;
NCI Metathesaurus CUI : CL474101;
Origin ID : C117233;
UMLS CUI : C3897094;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
