" /> Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F - CISMeF





Preferred Label : Autologous Bispecific BCMA/CD19-targeted CAR-T Cells GC012F;

NCIt synonyms : Autologous Anti-BCMA/CD19 Dual CAR T Cells GC012F; Autologous GC012F CAR-T Cells;

NCIt definition : A preparation of autologous T-lymphocytes engineered to express two separate chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) BCMA and CD19 and fused to as of yet not fully elucidated co-stimulatory domains, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous bispecific BCMA/CD19-targeted CAR-T cells GC012F specifically and simultaneously target and bind to tumor cells expressing BCMA and/or CD19. This induces selective toxicity in tumor cells that express BCMA and/or CD19. BCMA, a tumor-specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in the survival of B-lymphocytes and plasma cells. BCMA is found on the surfaces of B-cells and is overexpressed on malignant plasma cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies. The processing platform used, FasT CAR-T, shortens the manufacturing time to produce the CAR-T cells within 24 hours.;

Molecule name : GC-012F; GC 012F;

NCI Metathesaurus CUI : CL1412846;

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12/05/2024


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