Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes

Preferred Label : Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes;

NCIt synonyms : Autologous HCC Antigens-specific CD8-positive T-lymphocytes; Autologous Specific HCC Antigens CD8 T Cells; Autologous HCC Antigens-specific CD8 T lymphocytes;

NCIt definition : A preparation of autologous CD8-positive T-lymphocytes that are exposed, ex vivo, to multiple specific hepatocellular carcinoma (HCC) antigens, including glypican (GPC)-3, New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and alpha-fetoprotein (AFP), with potential immunostimulating and antineoplastic activities. Upon infusion of the GPC3/NY-ESO-1/AFP-specific CD8-positive T lymphocytes, the T-cells specifically target and lyse cells expressing the targeted HCC neoantigens.;

NCI Metathesaurus CUI : CL552567;

Details

Origin ID

C150676;

UMLS CUI

C4725915;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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