" /> Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T-lymphocytes - CISMeF





Preferred Label : Autologous Human Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T-lymphocytes;

NCIt synonyms : Anti-CD19-CAR Genetically Engineered Autologous T-lymphocytes huJCAR014; Anti-CD19-CAR Genetically Engineered Autologous T Lymphocytes huJCAR014; Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T-lymphocytes;

NCIt definition : A preparation of a defined ratio of CD4 and bulk CD8 autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing a human anti-CD19 single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous human anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4 /CD8 T-lymphocytes are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity.;

Molecule name : huJCAR014;

NCI Metathesaurus CUI : CL520585;

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15/05/2024


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