Autologous Anti-CD19 CAR-expressing T Lymphocytes - CISMeF
Autologous Anti-CD19 CAR-expressing T LymphocytesNCIt concept
Preferred Label : Autologous Anti-CD19 CAR-expressing T Lymphocytes;
NCIt synonyms : Autologous Anti-CD19-CAR T Cells;
NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express
a chimeric antigen receptor (CAR) that targets the human tumor associated antigen
(TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration,
autologous anti-CD19 CAR-expressing T lymphocytes bind to and induce selective toxicity
against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface
antigen expressed in all B-cell lineage malignancies.;