" /> Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718 - CISMeF





Preferred Label : Autologous MAGE-A3/A6-specific TCR Gene-engineered Lymphocytes KITE-718;

NCIt synonyms : MAGE-A3/A6 TCR Engineered T-lymphocytes; MAGE-A3/A6 T-Cell Receptor Engineered T-Cells KITE-718; MAGEA3/A6-targeted TCR-transduced T-Cells KITE-718; MAGE-A3/A6 T Cell Receptor Engineered T-Cells; Autologous Anti-MAGE-A3/A6 TCR-transduced T Cells KITE-718; TCR-transduced Autologous T-Cells KITE-718;

NCIt definition : Human autologous T-lymphocytes genetically modified to express a T-cell receptor (TCR) that specifically targets human melanoma-associated antigen A3 (MAGE-A3) and MAGE-A6 (MAGEA3/A6; MAGE-A3/A6), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with a gene expressing a TCR specific for the MAGE-A3/A6 antigens, expanded ex vivo, and reintroduced into the patient. Then, the autologous MAGE-A3/A6-specific TCR gene engineered lymphocytes KITE-718 target and bind to tumor cells expressing the MAGE-A3 and/or MAGE-A6 antigens. This halts the growth of and kills MAGE-A3/A6-expressing cancer cells. The tumor-associated antigens MAGE-A3 and MAGE-A6 are overexpressed on a variety of tumor cell types.;

Molecule name : KITE 718; KITE-718;

NCI Metathesaurus CUI : CL522896;

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15/05/2024


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