NCIt definition : A preparation of autologous human T-lymphocytes transduced with a lentiviral vector
encoding an affinity-enhanced T-cell receptor (TCR) specific for the human leukocyte
antigen (HLA)-A2-restricted peptide human melanoma antigen A4 (MAGE-A4) C1032, with
potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation,
transduction, expansion ex vivo, and reintroduction into the patient, afamitresgene
autoleucel targets and binds to tumor cells expressing MAGE-A4. This results in cell
death of MAGE-A4-expressing tumor cells. The tumor-associated antigen (TAA) MAGE-A4,
a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety
of cancer cell types.;