Preferred Label : Prime Cancer Vaccine MVA-BN-CV301;
NCIt synonyms : Prime Vaccine CV301; MVA-BN-CV301; MVA-BN Vaccine CV301; Modified Vaccinia Ankara-Bavarian Nordic Vaccine CV301;
NCIt definition : A cancer priming vaccine consisting of a proprietary version of the recombinant vaccinia
viral vector, modified vaccinia Ankara-Bavarian Nordic (MVA-BN), encoding both the
two human tumor-associated antigens (TAAs) carcinoembryonic antigen (CEA) and mucin-1
(MUC-1), and TRICOM, which is comprised of the three human immune-enhancing co-stimulatory
molecules B7-1, ICAM-1 and LFA-3, with potential immunostimulatory and antineoplastic
activities. Upon subcutaneous administration of MVA-BN-CV301, followed by multiple
boosting doses of the fowlpox virus (FPV) vaccine CV301, a cytotoxic T-lymphocyte
(CTL) response against CEA- and MUC-1-expressing tumor cells is activated. In addition,
the CV301-dependent anti-tumor CTL response upregulates the expression of programmed
cell death ligand 1 (PD-L1); therefore, when CV301 is combined with a programmed cell
death 1 (PD-1) immune checkpoint inhibitor, the antitumor effect may be increased.
CEA and MUC-1 are overexpressed in a variety of cancers.;
NCI Metathesaurus CUI : CL541455;
Origin ID : C143059;
UMLS CUI : C4684955;
Semantic type(s)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
