NCIt definition : A preparation of autologous peripheral blood T-lymphocytes (PBTLs) that have been
genetically modified to express a chimeric antigen receptor (CAR) specific for the
T-cell surface antigen CD4, administered with lymphodepletion, with potential immunostimulating
and antineoplastic activities. Upon administration, lymphodepleted autologous CD4-directed
CAR T cells specifically recognize and kill CD4-expressing tumor cells. CD4, a tumor-associated
antigen (TAA), is overexpressed in various lymphomas, including peripheral T-cell
lymphoma, angioimmunoblastic T-cell lymphoma and anaplastic large cell lymphoma.;