NCIt definition : A proprietary preparation of autologous T-lymphocytes that have been genetically modified
to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen
(TAA) CD19 and containing, as of yet undisclosed, costimulatory signaling domains,
with potential immunostimulating and antineoplastic activities. Upon administration,
autologous anti-CD19 CAR T-cells SJCAR19 target and bind to CD19-expressing tumor
cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 antigen
is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.;