" /> Autologous Anti-CD7-CAR-CD28zeta T-cells - CISMeF





Preferred Label : Autologous Anti-CD7-CAR-CD28zeta T-cells;

NCIt synonyms : Autologous CD7-CAR-CD28zeta-expressing T Cells; Autologous CRISPR-edited CD7-targeting CAR-CD28zeta T Cells; Autologous Anti-CD7-CAR/28zeta T-cells;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) directed against the CD7 antigen and linked to the co-stimulatory domains of CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta) (CD28zeta), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD7-CAR-CD28zeta T-cells specifically recognize and bind to CD7-expressing tumor cells, resulting in specific T-cell-mediated tumor cell lysis. CD7 is a transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors. It is expressed in the majority of lymphoblastic T-cell leukemias and lymphomas and in a subset of peripheral T-cell lymphomas.;

NCI Metathesaurus CUI : CL1773498;

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10/05/2024


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