Preferred Label : Autologous Peripheral Blood Lymphocytes Cotransduced with Retroviral Vectors Encoding
Inducible IL-12 and Anti-NY-ESO-1 TCR;
NCIt synonyms : Autologous PBL Cotransduced with Retroviral Vectors Encoding Inducible IL-12 and Anti-NY-ESO-1
TCR; Inducible IL-12/Anti-NY-ESO-1 TCR-Expressing Autologous PBL; IL-12/Anti-NY-ESO-1 TCR-Expressing Autologous PBL; IL-12/Anti-NY-ESO-1 TCR-Expressing Autologous Peripheral Blood Lymphocytes; Inducible IL-12/Anti-NY-ESO-1 TCR-Expressing Autologous Peripheral Blood Lymphocytes; Autologous Lymphocytes Cotransduced with Genes Encoding IL-12 and Anti-NY-ESO-1 TCR;
NCIt definition : Human autologous peripheral blood lymphocytes (PBLs) transduced with two retroviral
vectors, one encoding a T-cell receptor (TCR) specific for the cancer-testis antigen
NY-ESO-1 and a second that encodes an inducible single chain form of interleukin-12
(IL-12) driven by a nuclear factor of activated T-cells (NFAT)-responsive promoter,
with potential immunomodulating and antineoplastic activities. Following isolation
of lymphocytes, retroviral vector transduction, and expansion of the cells ex vivo,
the inducible IL-12/anti-NY-ESO-1 TCR-expressing autologous PBLs are re-administered
into the patient by intravenous injection. As the transduced PBLs traverse the patient's
circulation, they can bind to NY-ESO-1-overexpressing tumor cells. This binding activates
the TCR signaling pathway in the transduced PBLs, which promotes NFAT-dependent gene
transcription and induces expression of the cotransduced IL-12. IL-12 expression activates
the immune system by promoting the secretion of interferon-gamma, activating natural
killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both
decreased cell proliferation and increased cell death for the NY-ESO-1-overexpressing
tumor cells. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis
and on the surface of various tumor cell types. NFAT, a family of transcription factors
involved in immune responses, is activated by calcium signaling, which can occur downstream
of TCR activation. Use of a retroviral vector to express an inducible IL-12 may remove
the requirement for concomitant administration of interleukin-2 (IL-2) as is the case
for conventional cell transfer immunotherapies.;
Molecule name : IL-12 Plus anti-ESO-1 TCR PBL;
NCI Metathesaurus CUI : CL455235;
Origin ID : C113161;
UMLS CUI : C3827113;
Semantic type(s)
- Cell [UMLS semantic type]
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
