" /> Autologous BAFF-expressing CAR T Cells LMY-920 - CISMeF





Preferred Label : Autologous BAFF-expressing CAR T Cells LMY-920;

NCIt synonyms : BAFF CAR-T Cells LMY-920; Ligand-based BAFF CAR-T Cells LMY-920; BAFF Ligand-based CAR T-cells LMY-920;

NCIt definition : A preparation of autologous cluster of differentiation 4 (CD4) -and CD8 positive T-lymphocytes that are genetically engineered, using the non-viral transposon system, to express a chimeric antigen receptor (CAR) expressing the B-cell activating factor (BAFF) ligand and targeting BAFF receptor family members, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous BAFF-expressing CAR T cells LMY-920 are directed to, specifically bind to, and induce selective toxicity in tumor cells expressing any of the three BAFF receptor family members, including BAFF receptor (BAFF-R), B-cell maturation antigen (BCMA), and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Almost all B cell cancers are reported to express at least one of these three receptors which play a key role in the regulation of peripheral B-cell survival.;

Molecule name : LMY 920; LMY-920;

NCI Metathesaurus CUI : CL1792236;

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12/05/2024


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