" /> Abipapogene Suvaplasmid - CISMeF





Preferred Label : Abipapogene Suvaplasmid;

NCIt synonyms : VB10.16 Vaccine; DNA Vaccine VB10.16;

NCIt definition : A therapeutic DNA vaccine composed of three parts, one encodes the E6/E7 fusion protein of human papillomavirus (HPV) type 16 (HPV16), the second is a dimerization entity and the third part encodes a protein that specifically binds to antigen presenting cells (APCs), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration, abipapogene suvaplasmid expresses HPV16 E6/7 and a protein that targets receptors on APCs. Upon binding to APCs and subsequent internalization, the APCs mature and the HPV16 E6/7 antigenic protein is presented by the APCs. This attracts and stimulates B-lymphocytes, CD4-positive T-lymphocytes and elicits a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV16-associated E6 and E7 oncoproteins, which result in tumor cell lysis. HPV16 E6/7, a viral antigen, plays a key role in the development of certain types of cancer.;

UNII : D3XX2X6TBJ;

CAS number : 2939766-18-2;

Molecule name : VB-10.16;

NCI Metathesaurus CUI : CL498287;

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02/05/2025


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