NCIt synonyms : Autologous Follicle Stimulating Hormone Receptor-targeting Chimeric Endocrine Receptor
T Cells; Autologous Anti-FSHR Chimeric Endocrine Receptor-expressing T Cells; Autologous FSHR-specific 4-1BB/CD3zeta CER T-cells; Autologous FSHCER T Cells;
NCIt definition : A preparation of autologous human T-lymphocytes genetically modified to express a
chimeric endocrine receptor (CER) targeting the human follicle stimulating hormone
receptor (FSHR) and coupled to the signaling domains of 4-1BB (CD137) and CD3 zeta,
with potential immunostimulatory and antineoplastic activities. Upon administration,
the autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes target and bind
to the FSHR on FSHR-expressing tumor cell surfaces, thereby killing FSHR-expressing
tumor cells. FSHR is not normally expressed in healthy non-ovarian tissue, but is
present on several types of ovarian, fallopian tube, or primary peritoneal cancers.;