" /> Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes - CISMeF





Preferred Label : Autologous Anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes;

NCIt synonyms : Autologous Follicle Stimulating Hormone Receptor-targeting Chimeric Endocrine Receptor T Cells; Autologous Anti-FSHR Chimeric Endocrine Receptor-expressing T Cells; Autologous FSHR-specific 4-1BB/CD3zeta CER T-cells; Autologous FSHCER T Cells;

NCIt definition : A preparation of autologous human T-lymphocytes genetically modified to express a chimeric endocrine receptor (CER) targeting the human follicle stimulating hormone receptor (FSHR) and coupled to the signaling domains of 4-1BB (CD137) and CD3 zeta, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous anti-FSHR CER-4-1BB/CD3zeta-expressing T-lymphocytes target and bind to the FSHR on FSHR-expressing tumor cell surfaces, thereby killing FSHR-expressing tumor cells. FSHR is not normally expressed in healthy non-ovarian tissue, but is present on several types of ovarian, fallopian tube, or primary peritoneal cancers.;

NCI Metathesaurus CUI : CL1779147;

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26/05/2024


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