Anti-CEA IgCD28TCR-Transduced Autologous T Cells - CISMeF
Anti-CEA IgCD28TCR-Transduced Autologous T CellsNCIt concept
Preferred Label : Anti-CEA IgCD28TCR-Transduced Autologous T Cells;
NCIt definition : A population of autologous tumor infiltrating lymphocytes (TIL) transduced with a
retroviral vector encoding the chimeric gene IgCD28TCR with potential immunostimulating
and antineoplastic activities. The chimeric IgCD28TCR gene consists of portions of
CD28, the zeta chain of the T-cell receptor (TCRzeta), and a single chain antibody
domain (sFv) specific for the tumor-associated antigen CEA. Upon administration, these
gene-modified TIL bind to tumor cells expressing CEA, which may result in activation
and proliferation of TIL and an enhanced cytotoxic T-lymphocyte (CTL) response against
CEA-expressing tumor cells. CEA may be overexpressed in various gastrointestinal and
breast cancers. CD28, a T-cell surface-associated co-stimulatory molecule, is required
for full T-cell activation, proliferation, and survival; expression of the CD28 fragment
in this chimeric gene construct may impede activation-induced cell death (AICD) of
TIL.;