Autologous Anti-GPC3 CAR T Cells BOXR1030

Preferred Label : Autologous Anti-GPC3 CAR T Cells BOXR1030;

NCIt synonyms : Autologous Anti-GPC3 CAR-T Cells BOXR1030; Autologous Anti-GPC3 CAR T-cells BOXR1030; Autologous CAR-GPC3 T Cells BOXR1030;

NCIt definition : A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3) and glutamic-oxaloacetic transaminase 2 (GOT2) transgene, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC3 CAR T cells BOXR1030 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation. The inclusion of GOT2, a mitochondrial enzyme that plays an important role in cellular metabolism, may improve T-cell metabolic function and anti-tumor activity.;

Molecule name : BOXR 1030; BOXR-1030;

NCI Metathesaurus CUI : CL1773823;

Details

Origin ID

C185392;

UMLS CUI

C5666975;

Semantic type(s)
- Cell [UMLS semantic type]
chemical_or_drug_affects_cell_type_or_tissue
- Cytotoxic T-Lymphocyte [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Glypican-3 [NCIt concept]

Keyword's position in hierarchy(ies) :

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